Topical Corticosteroids: Pharmacology

Topical corticosteroids are widely used for inflammatory and hyperproliferative disorders in dermatology. Numerous topical corticosteroids with high local activity have been developed over the years, with a focus to develop drugs with high efficacy locally and minimum risk for adverse drug reactions. They are available in a number of formulations. Their therapeutic effects are a result of their anti-inflammatory, immunosuppressant, vasoconstrictive and anti-proliferative actions. An appropriate topical corticosteroid is selected on the basis of the dermatological condition to be treated, patient-related factors and the physicochemical properties of the drug. Their use is associated with mainly local adverse drug reactions, but prolonged use and/or use of highpotency topical corticosteroids may cause systemic effects.